The film follows the misadventures of Jack Skellington, Halloweentown's beloved pumpkin king, who has become bored with the same annual routine of frightening people in the "real world." When Jack accidentally stumbles on Christmastown, all bright colors and warm spirits, he gets a new lease on life -- he plots to bring Christmas under his control by kidnapping Santa Claus and taking over the role. But Jack soon discovers even the best-laid plans of mice and skeleton men can go seriously awry.

Hoping to cut a deal, a professional bank robber agrees to return all the money he stole in exchange for a reduced sentence. But when two FBI agents set him up for murder, he must now go on the run to clear his name and bring them to justice.